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Kringle Pharma Inc plasminogen kringle-4 like repeats
Plasminogen Kringle 4 Like Repeats, supplied by Kringle Pharma Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/kringle+4+repeats/plasminogen+kringle+5/us09913886-6-20-14
Average 90 stars, based on 1 article reviews
plasminogen kringle-4 like repeats - by Bioz Stars, 2026-09
90/100 stars

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Article Title: Relationship between plasma lipoprotein (a), apolipoprotein (a) phenotypes, and other coronary heart disease risk factors in a Melbourne South Asian population.
Article Snippet: Background: High plasma lipoprotein(a) [Lp(a)] level is a strong and important risk factor for cardiovascular disease (CVD).. Small-sized apolipoprotein(a) [apo(a)] isoforms (F, B, S1, and S2) are inversely correlated with the high levels of Lp(a) in plasma and significantly associated with CVD.. Although the effects of apo(a) phenotypes and various risk factors on Lp(a) status in South Asian population may have been studied in other countries, there are no reports involving these risk factors in Australia.

Article Title: Rhesus Monkey ( Macaca mulatta ) Lipoprotein(a) and Apolipoprotein(a): High Frequency of Small Size Apolipoprotein(a) Isoforms
Article Snippet: Lp(a) levels and apo(a) isoform distribution and dominance patterns table ft1 table-wrap mode="anchored" t5 caption a7 Characteristics Infants/Juveniles Adults Young Mature Aged Number, n (%) 8 (8%) 14 (15%) 70 (74%) 3 (3%) Female, n (%) 5 (63%) 13 (93%) 63 (90%) 2 (67%) Age (years) 2.0 ± 1.1 5.1 ± 0.4 11.0 ± 3.2 20.1 ± 1.3 Body weight (kg) 3.0 ± 1.5 6.6 ± 2.2 8.5 ± 2.2 8.1 ± 1.4 Lipoprotein(a), nmol/L 32 (23–82) 58 (29–72) 55 (23–108) 21 (11–49) Allele-specific apo(a), nmol/L 18 (13–36) 34 (9–57) 32 (14–73) 15 (6–27) Kringle 4 repeats 23 (15–25) 22 (14–25) 24 (14–26) 26 (21–28) Open in a separate window Data are reported as mean ± SD for age and body weight, and median (IQR) for Lp(a), allele-specific apo(a), and K4 repeats.

Article Title: Rhesus Monkey ( Macaca mulatta ) Lipoprotein(a) and Apolipoprotein(a): High Frequency of Small Size Apolipoprotein(a) Isoforms
Article Snippet: Kringle 4 repeats , 23 (15–25) , 22 (14–25) , 24 (14–26) , 26 (21–28).

Clinical Proteomics:

Article Title: Interaction of oestrogen and peroxisome proliferator-activated receptors with apolipoprotein(a) gene enhancers
Article Snippet: The apo(a) gene exhibits considerable size polymorphism related to the presence of different numbers of a tandemly repeated sequence similar to that of the fourth of the Kringle structures found in plasminogen [5,7]. .. There is a general inverse relationship between the number of these Kringle 4 repeats and plasma Lp(a) levels [8], resulting from the less efficient processing of the larger apo(a) isoforms and the consequently reduced availability of apo(a) for incorporation into Lp(a) [9,10]. ..

Article Title: 'Lipoproteins, glycoxidation and diabetic angiopathy'.
Article Snippet: The chronic vascular complications of diabetes (nephropathy, retinopathy and accelerated atherosclerosis) are a major cause of morbidity and premature mortality.. In spite of the more widespread availability of intensive diabetes management, approximately one in three people with diabetes develop aggressive complications and over 70% die of atherosclerosis-related diseases.. Genetic and acquired factors are likely to be contributory.

Quantitative Proteomics:

Article Title: Heterozygous apolipoprotein (a) status and protein expression as a risk factor for premature coronary heart disease.
Article Snippet: unique highly polymorphic glycoprotein, APO(a), which has serine protease and lysine-binding domains, one copy of kringle 5 domain, and multiple copies of kringle 4 domain.1 On the basis of amino-acid differences, 10 different types of kringle 4 domains are known, each present in a single copy except for type 2.2 Plasma APO(a) size heterogeneity is genetically determined by the number of type 2 kringle 4.3-43 Population studies have shown an inverse relationship between APO(a) size and LP(a) concentration.4 The APO(a) gene locus contributes to more than 90% of LP(a)-level variation and, in particular, the number of Heterozygous apolipoprotein (a) status and protein expression as a risk factor for premature coronary heart disease

Mann-Whitney U-Test:

Article Title: Heterozygous apolipoprotein (a) status and protein expression as a risk factor for premature coronary heart disease.
Article Snippet: unique highly polymorphic glycoprotein, APO(a), which has serine protease and lysine-binding domains, one copy of kringle 5 domain, and multiple copies of kringle 4 domain.1 On the basis of amino-acid differences, 10 different types of kringle 4 domains are known, each present in a single copy except for type 2.2 Plasma APO(a) size heterogeneity is genetically determined by the number of type 2 kringle 4.3-43 Population studies have shown an inverse relationship between APO(a) size and LP(a) concentration.4 The APO(a) gene locus contributes to more than 90% of LP(a)-level variation and, in particular, the number of Heterozygous apolipoprotein (a) status and protein expression as a risk factor for premature coronary heart disease



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